Anti-Interleukin-8 antibody produced in goat，0.1MG，I8026-.1MG，Sigma

General description

Interleukin 8 (IL-8) is an 8kD, 72 amino acid residue containing cytokine that belongs to C-X-C chemokine family . The IL-8 gene is mapped to human chromosome 4q13.3.

Immunogen

recombinant human IL-8 (CXCL8).

Application

Anti-Interleukin-8 antibody can be used for the following :

• For neutralizing the biological activity of recombinant human IL-8 and natural human IL-8.
• Immunoblotting.
• ELISA.

Biochem/physiol Actions

Interleukin 8 (IL-8) stimulates neutrophils to produce lysosomal enzymes along with myeloperoxidase, α-mannosidase and β-glucuronidase . Goat anti-Interleukin-8 antibody reacts specifically with recombinant and natural human IL-8 but not with recombinant human GROα. Elevated expression of the gene is observed in a number of cancers including chronic spontaneous urticaria and breast cancer, thus serves as a prognostic marker for the same. IL-8 regulates the metastasis and angiogenesis processes during cancer development. IL-8 is responsible for epithelial–mesenchymal transition which plays an important role in providing cancer cells the mobility to invade other neighbouring cells, thereby contributing to metastasis.
The antibody will neutralize the biological activity of recombinant and natural human IL-8, but not recombinant human GROα.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.