Anti-GPX1 antibody produced in rabbit，100UL，SAB5700925-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants and multiple pseudogenes of this gene have been identified.

Immunogen

A synthesized peptide derived from human GPX1

Physical form

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody product type	primary antibodies
clone	monoclonal
form	liquid
species reactivity	human, mouse, rat
concentration	0.37 mg/mL
technique(s)	immunohistochemistry: 1:50-1:200,western blot: 1:500-1:2000
UniProt accession no.	P07203
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... GPX1(2876)

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