Anti-TTLL11 antibody produced in rabbit，100UL，HPA021828-100UL，Sigma

General description

TTLL11 (Tubulin tyrosine ligase-like family, member 11) is a component of the neuronal tubulin polyglutamylase protein complex consisting of a TTL homology domain.

Immunogen

tubulin tyrosine ligase-like family, member 11 recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

TTLL11 (Tubulin tyrosine ligase-like family, member 11) is associated with various microtubule stability activities such as cilia beating, development, and neuronal function. It participates in the polyglutamylation of microtubule through either initiation reaction (addition of the first glutamate residue) or the elongation reaction. It has been studied that member of this TTLL family facilitates the joining of diverse amino acids to tubulins or other substrates. In the cilia development, TTLL11 helps CSAP (centriole and spindle-associated protein) for localization to microtubule structures.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Other Notes

Corresponding Antigen APREST75389

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany