Anti-CRTH2 (GRP44) antibody produced in rabbit,100UG,C0867-100UG,Sigma

销售价: ¥ 4404.33 / 件
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订货号 0BR6928
品牌型号 Sigma C0867-100UG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

Immunogen

peptide corresponding to the human CRTH2 (GRP44) protein, near the C-terminus (amino acids 329-348).


Application

Anti-CRTH2 (GRP44) antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:1,000 using CRTH2- transfected Jurkat cells.


Biochem/physiol Actions

CRTH2 (chemoattractant receptor-homologous molecule), is known as the putative G protein-coupled receptor (GP44), is expressed on T helper 2 (Th2) cells. It is also referred as DP2, DL1R and CD294. It′s a human protein and belongs to G protein-coupled leukocyte chemo attractant receptor family. It is not expressed on human amniocytes or myocytes. On activation of CRTH2, PGD(2) induces human osteoclast apoptosis and the apoptosis intrinsic pathway. CRTH2, CD4 and T cells all together may be involved in the pathogenesis of IgG4-related Lacrimal gland enlargement (LGE) causing Mikulicz′s disease (MD).


Physical form

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.


Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


技术参数 Specifications
biological sourcerabbit
Quality Segment200
conjugateunconjugated
antibody formaffinity isolated antibody
antibody product typeprimary antibodies
clonepolyclonal
formbuffered aqueous solution
mol wtantigen ~43 kDa by calculation
species reactivityrat, mouse, human
technique(s)western blot: 1:500-1:1,000 using CRTH2-transfected Jurkat cells
shipped indry ice
storage temp.−20°C
Gene Informationhuman ... GPR44(11251)
mouse ... Gpr44(14764)
rat ... Gpr44(309212)
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