Anti-phospho-FRS2 (pTyr⁴³⁶) antibody produced in rabbit，100UG，SAB4504670-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) is an FGF receptor (FGFR)-associated protein. It is a membrane-bound adaptor protein, that is located on human chromosome 12q15.

Immunogen

The antiserum was produced against synthesized peptide derived from human FRS2 around the phosphorylation site of Tyr436.

Immunogen Range: 402-451

Biochem/physiol Actions

Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) is essential for activation of downstream signaling molecules that are involved in the MAP (‎mitogen-activated protein kinase) and AKT (protein kinase B) kinase pathways. This protein plays an important role in epidermal growth factor (EGF) signaling. It also plays a major role in cell transformation and resistance to therapy. FRS2 helps to link FGF, nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF) receptors with the Ras/mitogen-activated protein (MAP) kinase signaling cascade.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Level	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen 57 kDa
species reactivity	rat, mouse, human
concentration	~1 mg/mL
technique(s)	ELISA: 1:10000,immunohistochemistry: 1:50-1:100,western blot: 1:500-1:1000
NCBI accession no.	Q8WU20
UniProt accession no.	Q8WU20
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	phosphorylation (pTyr436)
Gene Information	human ... FRS2(10818)

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