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FLT3 (571-993), active, GST tagged human，10UG，F6432-10UG，Sigma

销售价： ¥ 3895.98 / 件

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订货号： 0BR7953

品牌型号： Sigma F6432-10UG

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最小订货量： 1件

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产品介绍 Product Description

General description

FLT3 (fms-related tyrosine kinase 3) is a tyrosine kinase receptor and the gene is localized to human chromosome 13q12. The encoded protein is composed of 993 amino acids, and consists of five immunoglobulin (Ig)-like domains in its exoplasmic region. It is also composed of a transmembrane region, a juxtamembrane domain, and two tyrosine kinase domains in its intracellular domain. The tyrosine kinase domains are linked via a kinase-insert domain.

Biochem/physiol Actions

FLT3 (fms-related tyrosine kinase 3), upon interaction with its ligand, undergoes conformational changes to form homodimers. This results in phosphorylation and activation of downstream signaling pathways including phosphatidylinositol 3-kinase (PI3K/AKT), mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and signal transducer and activator of transcription 5 (STAT5) pathways. Internal tandem duplication (ITD) mutation or a point mutation in juxtamembrane domain-coding region or within the activation loop domain, respectively, of this gene lead to its constitutive action. FLT3/ITD mutation is associated with later stages of acute myeloid leukemia (AML) pathogenesis. These patients have poor prognosis.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

技术参数 Specifications

recombinant	expressed in baculovirus infected Sf9 cells
Quality Segment	200
product line	PRECISIO^® Kinase
assay	≥70% (SDS-PAGE)
form	buffered aqueous glycerol solution
specific activity	60-81 nmol/min·mg
mol wt	~73 kDa
UniProt accession no.	P36888
shipped in	dry ice
storage temp.	−70°C
Gene Information	human ... FLT3(2322)

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