Anti-FKBP52/FKBP4 Antibody, clone 3Q6H2, Rabbit Monoclonal，100UL，SAB5702448-100UL，Sigma

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订货号： 0BS3557

品牌型号： Sigma SAB5702448-100UL

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最小订货量： 1件

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商品介绍
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产品介绍 Product Description

General description

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

Immunogen

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human FKBP52/FKBP4 (Q02790).

Application

WB, IF/ICC

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
material	colorless
clone	3Q6H2, monoclonal
form	liquid
mol wt	56 kDa
species reactivity	human, rat
concentration	0.50 mg/mL
technique(s)	immunofluorescence: 1:50 - 1:200,western blot: 1:500 - 1:2000
color	colorless
isotype	IgG
immunogen sequence	MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDI
UniProt accession no.	Q02790
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... FKBP4(2288)

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