- 商品介绍
- 规格参数
- 包装参数
General description
Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.
The gene OPRM1 (opioid receptor μ 1) is mapped to human chromosome 6q24-q25. The gene spans a length of 200kb and contains 11 exons that yield 17 splice variants.
Immunogen
Peptide sequence around aa. 373-377 (H-P-S-T-A), according to the protein OPRM1.
Application
Anti-OPRM1 (Ab-375) antibody produced in rabbit has been used in Western blotting.
Biochem/physiol Actions
The gene OPRM1 (opioid receptor μ 1) encodes a μ opioid receptor that functions in pain perception and addiction to drugs of abuse, such as cocaine, nicotine and alcohol. It serves as a target for opioid drugs, such as morphine, methadone and heroin and opioid peptides (like β - endorphin and endomorphins) and mediates their effects. Single nucleotide polymorphism in the OPRM1 gene is associated with an inclination to drug addiction and lesser response to painful stimuli.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | ~80 kDa |
| species reactivity | mouse, rat |
| concentration | 1 mg/mL |
| technique(s) | western blot: 1:500-1:1000 |
| isotype | IgG |
| immunogen sequence | (H-P-S-T-A) |
| NCBI accession no. | NP_000905.3 |
| UniProt accession no. | P42866 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... OPRM1(4988) |
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