- 商品介绍
- 规格参数
- 包装参数
General description
AKT1 (v-akt murine thymoma viral oncogene homolog 1) is a Ser/Thr protein kinase, and is also called protein kinase B (PKB). This protein is activated when it is phosphorylated at serine 473 and threonine 308. This gene is localized to human chromosome 14q32.32.
Application
Akt1 active human has been used for the testing of recombinant mouse p21 proteins as its substrates using in vitro protein kinase assay.
Biochem/physiol Actions
AKT1 (v-akt murine thymoma viral oncogene homolog 1) is responsible for the phosphorylation and cytoplasmic localization of CKDN1A (cyclin-dependent kinase (CDK) inhibitor 1, also referred to as p21). However, p21 is one of the CDKNs which normally resides in the nucleus and its cytoplasmic localization, mediated by AKT1, is common to various cancers where it suppresses proteins essential for apoptosis. Studies show that up-regulation of AKT1 serves as a poor prognostic marker in breast cancer, which however, depends upon factors including population, hormone receptor status, and hormonal or trastuzumab therapy status.
| biological source | human |
| recombinant | expressed in baculovirus infected Sf9 cells |
| assay | ≥75% (SDS-PAGE) |
| form | aqueous solution |
| mol wt | 60.2 kDa |
| packaging | pkg of 10 μg |
| NCBI accession no. | NM_001014432 |
| UniProt accession no. | P31749 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... AKT1(207) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
询价
-
¥ 1563.36
-
¥ 8293.41
-
询价
-
询价
-
询价
-
询价
-
询价
-
询价
-
询价
-
瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmSFCA滤膜，孔径0.2um,适合瓶颈尺寸45mm，12/箱，291-4520，Nalgene，Thermofisher，赛默飞世尔¥ 2856.42
-
¥ 2268.97
-
¥ 1564.00
-
¥ 2869.87
-
¥ 2132.12
-
¥ 2452.91
-
¥ 2099.27
-
¥ 2173.94
-
¥ 56581.65
微信小程序
7X24小时在线咨询