Anti-Interleukin-2 antibody produced in goat，1MG，I8273-1MG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Interleukin-2 (IL-2) is a cytokine produced by activated T cells in response to antigen stimulation. IL-2 is important for proliferation of lymphocytes, natural killer cells and macrophages and in the differentiation of CD4⁺ cells into Th1 and Th2 effector cells. The effects of IL-2 are mediated by the signalling activated by its binding to IL-2 receptor (IL-2 R). IL-2 activates key signalling pathways such as MAPK, JAK/STAT as well as PI3K/Akt. Activation of these pathways modulates production of inflammatory cytokines, survival and progression through cell cycle
Monoclonal Anti-Interleukin-2 recognizes human Interleukin-2. It also neutralizes recombinant, mouse IL-2, but requires 30-50 times the antibody concentration required to neutralize human IL-2.

Immunogen

recombinant human interleukin-2 expressed in Escherichia coli.

Application

Anti-interleukin-2 antibody is suitable for IL-2 neutralization assays.

Biochem/physiol Actions

The antibody neutralizes the biological activity of recombinant human IL-2.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	goat
Quality Segment	100
conjugate	unconjugated
antibody form	IgG fraction of antiserum
antibody product type	primary antibodies
clone	polyclonal
form	lyophilized powder
species reactivity	human
technique(s)	neutralization: suitable,western blot: 1 μg/mL
UniProt accession no.	P60568
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... IL2(3558)

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