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General description
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Immunogen
A phospho specific peptide corresponding to residues surrounding S1387 of human Tuberin/TSC2.
Physical form
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | liquid |
| species reactivity | human, rat |
| concentration | 0.68 mg/mL |
| technique(s) | western blot: 1:500-1:2000 |
| UniProt accession no. | P49815 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer1387) |
| Gene Information | human ... TSC2(7249) |
| 长度(mm) | |
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