- 商品介绍
- 规格参数
- 包装参数
General description
Polo-like kinase 1 (PLK1) belongs to the polo-like kinase family. PLK1 is characterized with two COOH-terminal polo box domain and N-terminal kinase domain involved in drug development. PLK1 is expressed primarily at centrosomes and at the midbody of dividing cells.
Immunogen
The antiserum was produced against synthesized peptide derived from human PLK1 around the phosphorylation site of Ser137.
Immunogen Range: 103-152
Biochem/physiol Actions
Polo-like kinase 1 (PLK1) is involved in regulation of mitosis. PLK1 plays a crucial role in centrosome-mediated microtubule events and spindle assembly. PLK1 expression is elevated in cancer tissues. Thus, it can be used as a potential prognostic marker for several cancers, including non-small-cell lung cancer, squamous-cell carcinomas of the head and neck, melanomas, colorectal cancer, oropharyngeal carcinomas, and ovarian and endometrial carcinomas. PLK1 recruited to centrosomes during S-phase by centrosomal protein FOP-related protein of 20kDa (FOR20), plays a vital role in S-phase progression. The protein also plays an essential role in central spindle formation and cytokinesis. PLK1 inhibitors might act as a potential therapeutics in cancer treatment.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 68 kDa |
| species reactivity | mouse, human, rat |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:10000,western blot: 1:500-1:1000 |
| NCBI accession no. | P53350 |
| UniProt accession no. | P53350 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer137) |
| Gene Information | human ... PLK1(5347) |
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