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General description
The K+ channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM K+ channels based on the number of transmembrane domains. The voltage-gated Potassium or Kv channels belong to the 6 TM K+ channel family that also include other sub-types such as the hERG, KCNQ, and EAG channels. Kv11.1 belongs to the EAG family and facilitates the repolarization of normal action potential in heart muscles. Genetic alterations in Kv11.1 can cause heart disorders such as long QT syndrome, sudden cardiac death and arhythmias. Kv11.1 also regulates cell growth and hence may be studied as a target for cancer treatment. Anti-Potassium channel Kv11.1 extracellular antibodies are specific to Kv11.1.
Immunogen
peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human KV11.1. This sequence has 11/16 residues identical in mouse and rat and has 15/16 residues identical in rabbit and dog.
Application
Anti-Potassium channel Kv11.1 extracellular antibodies may be used in immunofluorescence microscopy . It may also be used for the detection of Kv11.1 by techniques such as immunocytochemistry, flow cytometry using live intact K562 (human chronic myelogenous leukemia) cells and western blotting.
Physical form
Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 200 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | lyophilized powder |
| species reactivity | human |
| technique(s) | flow cytometry: 2-8 μg using live intact K562 (human chronic myelogenous leukemia) cells (per 106 cells),immunocytochemistry: 1:25,western blot: 1:200 using HEK-KV11.1 transfected cells |
| web metadata keyword.default | Anti-Kv11.1 antibody rabbit,KCNH2 anti-HERG antibody 100µg,KCNH2 antibody flow cytometry,KCNH2 antibody for cardiac research,KCNH2 antibody rabbit 100µg,KCNH2 extracellular antibody for flow cytometry,anti-HERG KCNH2 extracellular antibody,anti-Kv11.1 EAG family antibody,anti-Kv11.1 antibody 1:200 dilution,anti-Kv11.1 antibody for HEK-KV11.1 cells,anti-Kv11.1 antibody for long QT syndrome,anti-Kv11.1 antibody,anti-Kv11.1 immunocytochemistry,rabbit anti-Kv11.1 antibody western blot,voltage-gated K+ channel antibody |
| UniProt accession no. | Q12809 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... KCNH2(3757) mouse ... Kcnh2(16511) rat ... Kcnh2(117018) |
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