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- 规格参数
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General description
Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2.
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4
Biochem/physiol Actions
Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
| biological source | rabbit |
| Quality Segment | 100 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous glycerol solution |
| species reactivity | human, mouse, rat |
| technique(s) | immunohistochemistry: 1:20-1:100,western blot: 1:500-1:2000 |
| accession no. | NP_001888 |
| UniProt accession no. | Q6UVK1 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... CSPG4(1464) |
| 长度(mm) | |
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询价
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¥ 1573.49
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¥ 2013.69
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¥ 3109.49
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询价
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询价
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询价
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¥ 3442.25
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询价
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¥ 3812.28
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmPES滤膜，孔径0.45um,适合瓶颈尺寸33mm，12/箱，295-3345，Nalgene，Thermofisher，赛默飞世尔¥ 1938.54
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¥ 2573.97
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¥ 2882.02
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¥ 2842.54
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¥ 1196.00
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¥ 1749.15
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¥ 2173.94
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