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General description
Interferon regulatory factor 9 (ISGF3G, IRF-9, p48) is a DNA-binding component of the heterotrimeric transcription factor ISGF3 which is activated by interferon-α and β (type I IFNs). The other two components of ISGF3 are STAT1 and STAT2. ISGF3 gamma or complexes containing ISGF3 gamma are involved in IRF-1-independent pathways mediating IFN gene regulation. ISGF3 plays a primary role in the transmission of a signal from the cell surface to the nucleus via regulatory factors p84/91 and p113.
Rabbit polyclonal anti-ISGF3G antibody reacts with pig, bovine, human, mouse, rat, and zebrafish interferon regulatory factor 9/ISGF3 gamma proteins.
Immunogen
Synthetic peptide directed towards the N terminal region of human ISGF3G
Application
Rabbit Anti-ISGF3G antibody can be used for western blotting applications at 2.5μg/ml.
Rabbit polyclonal anti-ISGF3G antibody is used to tag interferon regulatory factor 9/ISGF3 gamma for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of interferon regulatory factor 9/ISGF3 gamma in the mediation of interferon-α and β (type I IFNs) signaling.
Biochem/physiol Actions
ISGF3G functions to recruit RNA polymerase II to the promoter of interferon-stimulated genes and requires histone deacetylases. Defects in ISGF3 can cause resistance to IFN-.(2a) treatment.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: PWKHAGKQDFREDQDAAFFKAWAIFKGKYKEGDTGGPAVWKTRLRCALNK
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | 44 kDa |
| species reactivity | rabbit, human, rat, bovine, mouse, guinea pig, dog, horse |
| concentration | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| web metadata keyword.default | Anti-IRF-9 antibody rabbit,Anti-ISGF3 antibody Sigma-Aldrich,Anti-ISGF3G antibody for gene regulation studies,Anti-ISGF3G antibody for protein analysis,Anti-ISGF3G antibody immunohistochemistry,Anti-ISGF3G antibody rabbit,Anti-ISGF3G antibody,Anti-ISGF3G p48 antibody 100µg,ISGF3 gamma antibody for research,ISGF3 transcription factor antibody,ISGF3G antibody for cell signaling studies,high purity Anti-ISGF3G antibody,monoclonal Anti-ISGF3 antibody rabbit,p48 antibody for western blot,rabbit Anti-IRF-9 antibody for immunofluorescence |
| NCBI accession no. | NP_006075 |
| UniProt accession no. | Q00978 |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | human ... ISGF3G(10379) |
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¥ 1451.54
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¥ 1196.00
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¥ 3404.94
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¥ 10685.48
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¥ 5804.96
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¥ 2888.88
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¥ 65710.50
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¥ 52185.37
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¥ 57595.03
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