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Monoclonal Anti-Hepatocyte Growth Factor antibody produced in mouse，500UG，H0665-500UG，Sigma

销售价： ¥ 8595.98 / 件

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订货号： 0BS9947

品牌型号： Sigma H0665-500UG

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最小订货量： 1件

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产品介绍 Product Description

General description

Hepatocyte Growth Factor (HGF) is a multifunctional, heparin-binding factor that stimulates the proliferation of liver cells. The cellular effects of HGF are mediated by its receptor, c-Met, that leads to significant activation of ERK, Src/FAK, STAT3 and PI3K signaling. Cells of mesenchymal origin express HGF that stimulates the c-Met expression via an autocrine loop. Various functions of the HGF/c-Met signaling include proliferation, cell survival, motility and adhesion and tissue regeneration. Apart from liver, HGF also mediates regeneration of kidney, lung and gastro-intestines. It is also important for maintaining the insulin production and prevents hypoglycemia, self-repair of cartilage, muscle and skin and hematopoiesis. The HGF/c-Met signaling is reported as a promising therapeutic target in prevention of angiogenesis in cancer and maintaining synaptic plasticity in Alzheimer′s disease
Monoclonal Anti-Hepatocyte Growth Factor recognizes human HGF. The antibody shows less that 0.25% cross-reactivity with recombinant human Macrophage Stimulating Protein (MSP).

Immunogen

purified, Sf21-derived recombinant human hepatocyte growth factor.

Application

Anti-Hepatocyte Growth Factor antibody may be used for ELISA at a concentration range of 2-8 μg/ml. For immunoblotting, a working concentration of 1-2 μg/ml is recommended.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	mouse
Quality Segment	100
conjugate	unconjugated
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	24516, monoclonal
form	lyophilized powder
species reactivity	human
technique(s)	capture ELISA: 2-8 μg/mL,western blot: 1-2 μg/mL
isotype	IgG1
UniProt accession no.	P05112
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... IL4(3565)

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