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Biochem/physiol Actions
7,8-Dimethoxyperphenazine is a cell penetrant inhibitor of UHM (U2AF homology motif) -ULM (U2AF ligand motif) interactions that interacts with the tryptophan binding pocket of different UHM domains including SPF45, PUF60 and U2AF. 7,8-Dimethoxyperphenazine inhibits early spliceosome assembly on pre-mRNA substrates in vitro.
cell penetrant inhibitor of UHM (U2AF homology motif) -ULM (U2AF ligand motif) interactions that interacts with the tryptophan binding pocket of UHM domains
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | ClC1=CC=C2C(N(CCCN3CCN(CCO)CC3)C(C=C(C(OC)=C4)OC)=C4S2)=C1 |
| InChI key | GKWVWOUUPIERSK-UHFFFAOYSA-N |
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