Anti- Cyclin D1 antibody produced in rabbit,100UL,SAB5701174-100UL,Sigma

销售价: ¥ 4030.96 / 件
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订货号 0BT4560
品牌型号 Sigma SAB5701174-100UL
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]


Immunogen

A synthesized peptide derived from human Cyclin D1


Physical form

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.


技术参数 Specifications
biological sourcerabbit
Quality Segment100
conjugateunconjugated
antibody product typeprimary antibodies
clonemonoclonal
formliquid
species reactivitymouse, human, rat
concentration0.38 mg/mL
technique(s)western blot: 1:500-1:2000
UniProt accession no.P24385
shipped inwet ice
storage temp.−20°C
target post-translational modificationunmodified
Gene Informationhuman ... CCND1(595)
长度(mm)
宽度(mm)
高度(mm)
重量(kg)
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