- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
Cdc34 is an essential gene for viability in yeast. Cdc34 mediates the transition from G1 to S-phase of the cell cycle by degrading the S-phase cyclin/CDK inhibitor, SIC1 in yeast and p27(KIP1) in human. Cdc34 is also known to interact with the Skp1/Cdc53/F-box (SCF) ubiquitin ligase subunits Cul1 to degrade the NF-κB inhibitor IκBα in a phosphorylation-dependent manner.
Infected cell protein 0 of herpes simplex virus 1 was shown to bind UbcH3 and induce its degradation by promoting its polyubiquination. This resulted in increased expression of an UbcH3-target gene cyclin D1 and aided in further viral infection.
Physical form
Solution in 50 mM HEPES, 200 mM NaCl, 1 mM TCEP (pH 7.5), and 10% glycerol.
Other Notes
Manufactured for Sigma by Boston Biochem. Inc.
| biological source | human |
| Quality Level | 200 |
| recombinant | expressed in E. coli overproducing strain |
| assay | ≥95% (SDS-PAGE) |
| form | solution |
| mol wt | ~32 kDa |
| UniProt accession no. | P49427,P61088 |
| application(s) | cell analysis |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... CDC34(997), UBE2N(7334) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
¥ 2013.69
-
¥ 1302.89
-
¥ 4039.86
-
询价
-
询价
-
询价
-
询价
-
¥ 2883.61
-
询价
-
询价
-
无菌，PETG 方形有刻度培养基瓶，带盖，聚对苯二酸乙二醇酯共聚物，天然高密度聚乙烯盖，500毫升容量，每箱40，40/箱，342020-0500，Nalgene，Thermofisher，赛默飞世尔¥ 3684.34
-
¥ 4404.38
-
¥ 2842.54
-
¥ 2277.64
-
¥ 3476.87
-
¥ 5426.00
-
¥ 26022.64
-
¥ 65710.50
-
¥ 25008.19
微信小程序
7X24小时在线咨询