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Biochem/physiol Actions
Potent and highly selective inhibitor of the acetylcholine-activated inward rectifier potassium current (IKACh) that exhibits an antiarrhythmic effect
XAF-1407 is a potent and highly selective inhibitor of the acetylcholine-activated inward rectifier potassium current (IKACh) that exhibits an antiarrhythmic effect in a goat and horse models of atrial fibrillation. XAF-1407 potently and selectively inhibits ion channels formed by Kir3.1/3.4 heterotetramers and Kir3.4 homotetramers that carry the IKACh current (IC50 of 1.1 and 3.2 nM respectively).
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | OC1(CN(C1)C2=C(C3=C(N=CN=C3S2)N4CCC(CC4)COCCN5CCCC5)C6=CC=CC=C6)C |
| InChI | 1S/C28H37N5O2S/c1-28(34)18-33(19-28)27-23(22-7-3-2-4-8-22)24-25(29-20-30-26(24)36-27)32-13-9-21(10-14-32)17-35-16-15-31-11-5-6-12-31/h2-4,7-8,20-21,34H,5-6,9-19H2,1H3 |
| InChI key | AVTFTJSBFXQTLR-UHFFFAOYSA-N |
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¥ 1596.77
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¥ 4404.38
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¥ 2406.69
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¥ 3896.11
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¥ 9909.51
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¥ 66743.99
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¥ 37675.92
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¥ 15537.49
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¥ 46052.83
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