Monoclonal Anti-Interleukin-4 antibody produced in mouse，500UG，I7034-500UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4 have been reported in cancers of breast, liver and renal cells
Anti-Interleukin-4 specifically recognizes human interleukin-4 (12-20 kDa). It does not react with mouse IL-4.

Immunogen

purified, E. coli-derived recombinant human interleukin-4.

Application

Anti-Interleukin-4 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For immunohistochemistry, a working concentration of 15 μg/ml may be used for human tissues and 5-15 μg/ml may be used for human cells. The antibody is suitable for neutralization reactions.

Physical form

Lyophilized from 0.2 μm-filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	mouse
Quality Segment	100
conjugate	unconjugated
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	3007, monoclonal
form	lyophilized powder
species reactivity	human
technique(s)	immunohistochemistry: 5-15.0 μg/mL,neutralization: suitable,western blot: 1-2 μg/mL
isotype	IgG1
UniProt accession no.	P05112
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... IL4(3565)

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