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Biochem/physiol Actions
Human type 3 TGF-β receptor sequence-derived TGF-beta1 (TGF-β1) inhibitor that blocks TGF-β1-mediated responses in vitro and in vivo.
P144 (Disitertide) is a 14-aa peptide TGF-beta1 (TGF-β1) inhibitor whose sequence corresponds to aa731-744 of human type 3 TGF-β receptor (UniProt Q03167). P144 blocks TGF-β1 from binding the type 3 TGF-β receptor and inhibits TGF-β1-mediated responses in vitro (80% MV1Lu growth inhibition by 200 μg/mL P144 in the presence of 200 pg/mL human TGF-β1) and in vivo (57% inhibition of hepatic stellate cells (HSCs) activation in a rat model of CCl4 inhalation-induced cirrhosis/hepatic fibrosis; 70 μg P144/rat via q.o.d. i.p.).
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Hygroscopic
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | (Powder or Lyophilized powder or film) |
| storage condition | desiccated |
| color | white to off-white |
| storage temp. | -10 to -25°C |
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¥ 1956.41
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¥ 3812.28
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¥ 15214.65
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¥ 3335.66
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¥ 1564.00
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¥ 1156.91
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¥ 787.34
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¥ 3796.67
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¥ 56581.65
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¥ 18741.69
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¥ 30616.15
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¥ 51962.23
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