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- 包装参数
General description
Lacks the mitochondrial targeting sequence but maintains the ability to neutralize pro-apoptotic Bcl-2 family members.
This recombinant Bcl-w lacks the mitochondrial targeting sequence but maintains the ability to neutralize pro-apoptotic Bcl-2 family members.
Biochem/physiol Actions
Anti-apoptotic member of the Bcl-2 family that prevents release of cytochrome c from the mitochondrial intermembrane space into the cytosol; promotes cell survival.
Like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. Bcl-w is an anti-apoptotic member of the Bcl-2 family that prevents release of cytochrome c from the mitochondrial intermembrane space into the cytosol. It is required for normal sperm maturation. Natural Bcl-w contains a C-terminal mitochondrial targeting sequence.
Physical form
Supplied as a 0.2 μm filtered solution in 25 mM HEPES, pH 7.5, 0.1 M KCl, and 10% glycerol.
Analysis Note
Measured by its ability to inhibit caspase-8-cleaved human BID-mediated release of cytochrome c from isolated mouse liver mitochondria using ELISA.
| recombinant | expressed in E. coli |
| Quality Segment | 200 |
| assay | >95% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| mol wt | 18 kDa by SDS-PAGE |
| UniProt accession no. | Q92843 |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | human ... BCL2L2(599) |
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¥ 1596.77
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¥ 1563.36
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¥ 1866.29
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¥ 20380.83
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¥ 2151.46
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¥ 1301.36
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¥ 1196.14
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¥ 1783.21
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¥ 1586.69
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¥ 2173.94
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NALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/8 x 1/4 x 1/16，英寸，每箱数量50，50/箱，8000-0020，Thermofisher，赛默飞世尔
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