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General description
Lysyl oxidase like 2 (LOXL2) is part of the LOX family of proteins. It is widely expressed. The gene encoding this protein is localized on human chromosome 8p21.3. It has a conserved carboxy-terminal region with a catalytic function and a divergent amino-terminal region.
Human LOXL2 (GenBank Accession No. NM_002318), amino acids 26 – 774 (end) with C-terminal His tag, MW = 85 kDa, expressed in FreeStyle 293-F cells.
Biochem/physiol Actions
Lysyl oxidase like 2 (LOXL2) is an amino oxidase. LOXL2 is involved in various cellular events such as gene transcription, cell migration, adhesion and differentiation. The protein has a role in connecting collagen and/or elastin in the extracellular matrix. It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 suppresses some TFIID (transcription factor IID)-associated genes by oxidising methylated TAF10 (TATA-box binding protein associated factor 10). The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion and lymph node metastasis.
Physical form
Formulated in 8 mM PBS, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol.
Legal Information
FreeStyle is a trademark of Invitrogen Corp.
| biological source | human |
| recombinant | expressed in FreeStyle™ 293-F cells |
| assay | ≥86% (SDS-PAGE) |
| form | aqueous solution |
| mol wt | 85 kDa |
| packaging | pkg of 10 μg |
| storage condition | avoid repeated freeze/thaw cycles |
| concentration | 0.23 mg/mL |
| NCBI accession no. | NM_002318 |
| UniProt accession no. | Q9Y4K0 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... LOXL2(4017) |
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