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General description
GST-tagged, full-length human p53
p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain.
Application
可用于研究 p53 的翻译后修饰或蛋白质-蛋白质相互作用研究。
Biochem/physiol Actions
p53基因高度保守，在正常组织中表达。它是人类癌症中最常见的突变基因，研究人员已经描述了各种类型的恶性肿瘤、血液肿瘤和实体肿瘤中的500 多个基因突变。完整的 p53 功能对于维持细胞的非致瘤性表型至关重要。因此， p53在抑制癌症的发展中起着至关重要的作用。。
| biological source | human |
| Quality Segment | 200 |
| recombinant | expressed in E. coli |
| assay | ≥90% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| UniProt accession no. | P04637 |
| application(s) | genomic analysis |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | human ... TP53(7157) |
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