- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of ABL protein is negatively regulated by its SH3 domain and deletion of the SH3 domain turns ABL1 into an oncogene. Translocation and head-to-tail fusion of the BCR and ABL1 genes is present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDK1-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Physical form
Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
| recombinant | expressed in baculovirus infected Sf9 cells |
| Quality Segment | 200 |
| product line | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| specific activity | 717-971 nmol/min·mg |
| mol wt | ~135 kDa |
| UniProt accession no. | P00520 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | mouse ... Abl1(11350) |
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¥ 2814.26
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¥ 1573.49
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¥ 1866.29
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¥ 8293.41
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¥ 1956.41
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¥ 3152.47
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¥ 2617.87
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¥ 1476.00
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¥ 5061.38
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¥ 2132.12
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¥ 2099.27
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