- 商品介绍
- 规格参数
- 包装参数
General description
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of immunoglobulin family serving as adhesive molecule which is ubiquitously expressed in nervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on T cells and NK cells. Polysialic modification results in reduction of CD56-mediated cell adhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumours and ovarian granulosa cell tumours.
Immunogen
KG-1 human acute myelogenous leukemia cell line
Biochem/physiol Actions
The antibody MEM-188 reacts with an extracellular epitope on a 180 kDa isoform of CD56 (NCAM) expressed in leukocytes. It has been suggested that the antibody MEM-188 could react with rhesus monkey lymphocytes. Reactivity with other NCAM isoforms has not been tested.
Physical form
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Preparation Note
Purified antibody is conjugated with activated Peridinin-Chlorophyll Protein (PerCP) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Other Notes
The antibody solution should be gently mixed before use.
| conjugate | Peridinin-Chlorophyll-Protein Complex conjugate |
| Quality Segment | 100 |
| antibody product type | primary antibodies |
| clone | MEM-188, monoclonal |
| form | buffered aqueous solution |
| species reactivity | (Non-human primates), ( Human) |
| technique(s) | flow cytometry: suitable |
| isotype | IgG2a |
| UniProt accession no. | P13591 |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| Gene Information | human ... NCAM1(4684) |
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