Anti-Collagen XVIII α1 antibody produced in rabbit，100UG，SAB4503213-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Endostatin is a naturally occurring 20kDa polypeptide derived from the C-terminal portion of type XVIII collagen. It functions as an anti-angiogenic cytokine that is expressed in various organs with the highest levels in liver, lung and kidney. The gene encoding it is localized on human chromosome 21q22.3. Anti-Collagen XVIII α1 Antibody detects endogenous levels of total Collagen XVIII α1 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Collagen XVIII alpha1.

Immunogen Range: 801-850

Biochem/physiol Actions

Endostatin inhibits the proliferation and migration of endothelial cells. It blocks apoptosis of cells and G1 to S phase transition in the cell cycle. It inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Mutations in this gene lead to Knobloch Syndrome (KS), a rare autosomal recessive disorder.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
mol wt	antigen 178 kDa
species reactivity	human, mouse
concentration	~1 mg/mL
technique(s)	ELISA: 1:5000,immunofluorescence: 1:100-1:500,immunohistochemistry: 1:50-1:100
NCBI accession no.	P39060
UniProt accession no.	P39060
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... COL18A1(80781)

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