Pepstatin A Methyl Ester，1MG，516485-1MGCN，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

A cell-permeable methyl ester derivative of Pepstatin A (Cat. No. 516481) that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase (K_is = 150 nM, K_ii = 320 nM in solubilized human γ-secretase at 20°C; K_is is the inhibition constant for inhibitor binding to the free enzyme and K_ii is the inhibition constant for inhibitor binding to the Enzyme-Substrate complex). Sta = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
γ-secretase
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

Other Notes

Tian, G., et al. 2002. J. Biol. Chem.277, 31499.
Zhang, L., et al. 2001. Biochemistry40, 5049.
Murphy, M.P., et al. 1999. J. Biol. Chem.274, 11914.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

技术参数 Specifications

Quality Segment	100
assay	≥95% (HPLC)
form	lyophilized
manufacturer/tradename	Calbiochem^®
storage condition	OK to freeze
solubility	DMSO: 5 mg/mL
web metadata keyword.default	Isovaleryl-V V-Sta-A-Sta-OCH₃ for drug discovery,Pepstatin A Methyl Ester 100mg,Pepstatin A Methyl Ester 25mg,Pepstatin A Methyl Ester K_ii 320 nM,Pepstatin A Methyl Ester K_is 150 nM,Pepstatin A Methyl Ester chemical structure,Pepstatin A Methyl Ester for research,Pepstatin A Methyl Ester inhibitor γ-secretase,Pepstatin A Methyl Ester purification grade,Pepstatin A Methyl Ester research applications,Pepstatin A Methyl Ester transition-state analog,Pepstatin A Methyl Ester,Sigma-Aldrich Pepstatin A Methyl Ester,lab-grade Pepstatin A Methyl Ester
shipped in	wet ice
storage temp.	−20°C

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