Anti-Tau Antibody, clone Tau 7，100UG，MAB2239，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Microtubule Associated Proteins, or MAPS, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I, II. Type II MAP includes MAP2, MAP4, and tau and are found in nervous tissue. Six tau isoforms exist in brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains.
50-68 kDa

Application

This Anti-Tau Antibody, clone Tau 7 is validated for use in WB for the detection of Tau.

Biochem/physiol Actions

Cat. # MAB2239 recognizes the C-terminus region of Tau.
Reactivity with other species has not been determined.

Physical form

Format: Purified

Analysis Note

Western Blot:

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

技术参数 Specifications

biological source	mouse
Quality Segment	100
antibody form	purified antibody
antibody product type	primary antibodies
clone	Tau 7, monoclonal
species reactivity	human, rat
technique(s)	western blot: suitable
isotype	IgG1κ
NCBI accession no.	NP_001116538.1
UniProt accession no.	P10636
shipped in	wet ice
target post-translational modification	unmodified
Gene Information	human ... MAPT(4137) rat ... Mapt(29477)

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