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General description
92.93 kDa calculated.
CUB domain-containing protein 1 (UniProt: Q9H5V8; also known as Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Transmembrane and associated with Src kinases, CD318) is encoded by the CDCP1 (also known as TRASK) gene (Gene ID: 64866) in human. CUB domain-containing protein 1 is a single-pass membrane protein that is synthesized with a 29 amino acid signal peptide, which is subsequently cleaved to generate the mature form. A soluble form of CUB domain-containing protein 1 has also been reported that is produced by proteolytic cleavage at the cell surface. CUB domain-containing protein 1 is highly expressed in mitotic cells with low expression during interphase. It is detected at highest levels in skeletal muscle and colon. Lower expression is reported in kidney, small intestine, placenta, and lung. It is also reported in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. CUB domain-containing protein 1 levels are up-regulated in a number of human tumor cell lines and in colorectal cancer, breast carcinoma and lung cancer. It is reported to be involved in cell adhesion and cell matrix association and may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation.
Immunogen
Epitope: extracellular domain
His-tagged recombinant fragment corresponding to 638 amino acids from the internal region of human CUB domain-containing protein 1.
Application
Anti-CDCP1 (CD318), clone 9A2, Cat. No. MABT861, is a mouse monoclonal that detects CUB domain-containing protein 1 and has been tested for use in Flow Cytometry.
Flow Cytometry Analysis: 1 µg from a representative lot detected CDCP1 CD318 in MDA-MB231 cells.
Research Category
Cell Structure
Biochem/physiol Actions
Clone 9A2 detects CUB domain-containing protein 1 in human and murine cells. It targets an epitope within the extracellular domain.
Physical form
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G purified
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Flow Cytometry in DLD-1 cells.
Flow Cytometry Analysis: 1 µg of this antibody detected CDCP1 CD318 in one million DLD-1 cells.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 9A2, monoclonal |
| species reactivity | mouse, human |
| packaging | antibody small pack of 25 μg |
| technique(s) | flow cytometry: suitable |
| isotype | IgG2bκ |
| NCBI accession no. | NP_073753.3 |
| UniProt accession no. | Q9H5V8 |
| target post-translational modification | unmodified |
| Gene Information | human ... CDCP1(64866) |
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