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General description
220 kDa
Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).
Immunogen
Epitope: PDZ2 domain of Scribble
GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble
Application
Research Sub Category
Tumor Markers
Cytoskeleton
This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.
Suggested dilutions:
Western blot: 0.2 µg (1:2000)
Biochem/physiol Actions
Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.
Physical form
Format: Purified
Purified in PBS containing with 0.05% NaN3.
Preparation Note
Maintain at 2-8°C for up to 1 year after date of receipt.
Analysis Note
Routinely evaluated by Western blot on HeLa cell lysates.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | 7C6.D10, monoclonal |
| species reactivity | human |
| manufacturer/tradename | Chemicon® |
| technique(s) | western blot: suitable |
| isotype | IgG1κ |
| GenBank accession no. | AAL38976 |
| UniProt accession no. | Q14160 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... SCRIB(23513) |
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¥ 3275.78
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