- 商品介绍
- 规格参数
- 包装参数
General description
HIV and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G-protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors (1,2). Among them, CCR5 is a principle coreceptor for macrophage- and dual-tropic HIV-1 strains fusion of entry of human white blood cells (3,4). The amino-terminal domain and the extracellular loops of CCR5 serve as HIV binding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
Immunogen
Epitope: N-terminus
Synthetic peptide from the N-terminal domain of human CCR5.
Application
Anti-C-C Chemokine Receptor 5 Antibody, N-terminus is an antibody against C-C Chemokine Receptor 5 for use in WB.
Research Category
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors
Western blot: 1:1000 - 1:2000 (THP-1 whole cell lysate can be used as a positive control)
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
Specific for human C-C Chemokine Receptor 5 (CCR5) at the N-terminus.
Physical form
Format: Purified
Purified immunoglobulin. 100 μg purified IgG in 100 μL of PBS containing 0.2% sodium azide.
Preparation Note
Store at 2-8°C for up to 12 months.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | polyclonal |
| species reactivity | human |
| manufacturer/tradename | Chemicon® |
| technique(s) | western blot: suitable |
| NCBI accession no. | NM_000579.3,NM_001100168.1 |
| UniProt accession no. | P51681 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... CCR5(1234) |
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¥ 1596.77
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¥ 1259.40
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¥ 8520.40
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¥ 5725.45
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¥ 4897.21
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¥ 2617.87
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¥ 2307.00
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¥ 1301.36
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