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General description
86 kDa calculated
CD44, also known as H-CAM is a distinct adhesion molecule that, with its 13 known isoforms, comprises a family of transmembrane glycoproteins involved in a wide variety of significant biological processes. Members belonging to this family are involved in apoptosis, migration, metastasis, tumor progression, lymphocyte homing, and the attachment of hematopoietic cells to stromal cells. CD44 is the primary cell surface receptor for hyaluronic acid (HA), and is also a notable target for WNT signaling within the intestinal mucosa. Recent studies have used CD44 marker as a means to isolate different cancer stem cells (CSC) such as; colorectal CSC, pancreatic CSC, and prostate CSC.
Immunogen
Epitope: Near the hyaluronate binding domain
Mouse bone marrow-derived stromal cells
Application
Detect mouse CD44 (H-CAM) using this Anti-mouse CD44 (H-CAM) Antibody, clone KM201 validated for use in FC.
Research Category
Cell Structure
Stem Cell Research
Research Sub Category
Adhesion (CAMs)
Hematopoietic Stem Cells
Biochem/physiol Actions
The antibody recognizes CD44 near the hyaluronate binding domain.
Physical form
Format: Purified
Protein G
Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Mouse bone marrow cells
Evaluated by Flow Cytometry in mouse bone marrow cells.
Flow Cytometry Analysis: 0.1 µg of this antibody detected CD44 in mouse bone marrow cells.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: CBL1308
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rat |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | KM201, monoclonal |
| species reactivity | mouse |
| technique(s) | flow cytometry: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_001034240 |
| UniProt accession no. | P15379 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... CD44(960) |
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