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General description
Research area: Cell Signaling Protein Target: MEK1 Target Sub-Family: STE
MEK1
N-terminal GST and Cterminal His6-tagged, recombinant full-length human MEK1
Biochem/physiol Actions
Mitogen-activated protein kinase kinase 1 (MEK1) is a hydrophilic non-receptor protein kinase that shows ubiquitous expression across different cell types. It serves as a critical component of the RAS-RAF-MEK-ERK signal transduction cascade, also known as the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) cascade. This signaling pathway plays a crucial role in regulating various biological processes, including apoptosis, cell cycle progression, cell migration, differentiation, metabolism, and proliferation. Additionally, MEK1 protein contributes to the development of the extra-embryonic ectoderm during placentogenesis. Somatic mutations in the MEK1 gene have been observed in individuals with melanoma, a form of skin cancer.
Packaging
Also available in 10 μg size and in bulk
Also available in 250μg size as catalog # 14-429M - Call for pricing and availability.
Physical form
Purified using glutathione agarose followed by Ni2+/NTA agarose, activated using c-Raf and the re-purified using Ni2+/NTA agarose
Preparation Note
1 year at -70°C
Analysis Note
routinely evaluated by phosphorylation of MBP
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | human |
| Quality Segment | 100 |
| recombinant | expressed in E. coli |
| product line | Upstate® |
| form | liquid |
| specific activity | (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.) |
| shelf life | 1 yr |
| mol wt | Mw 71 kDa |
| purified by | (Purified using glutathione agarose followed by Ni2+/NTA agarose, activated using c-Raf and the re-purified using Ni2+/NTA agarose) |
| species reactivity | human |
| manufacturer/tradename | Upstate® |
| technique(s) | activity assay: suitable (kinase) |
| solubility | soluble |
| accession no. | (FUNCTION: SwissProt: Q02750 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases. ),NM_002755.2 |
| NCBI accession no. | NM_002755.2 |
| UniProt accession no. | Q02750 |
| storage temp. | −70°C |
| Gene Information | human ... MAP2K1(5604) |
| 长度(mm) | |
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| 重量(kg) |
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¥ 2622.09
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¥ 1866.29
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¥ 8520.40
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¥ 8137.12
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