Anti-CD28 Antibody (human), PE, clone CD28.2，25TESTS，MABF558，Sigma

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订货号： 0BV4598

品牌型号： Sigma MABF558

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最小订货量： 1件

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产品介绍 Product Description

General description

The CD28.2 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICCOS and BTLA.The CD28.2 antibody may be used as a phenotypic marker for human CD28, expressed on all CD4+ T cells and CD8+ T cells, and is widely used as a reagent for activation of the CD28 receptor in vitro and in vivo. This antibody is also reported to be cross-reactive with several non-human species, including Baboon, Chimpanzee, Cynomolgus, and Rhesus.
This mouse monoclonal antibody Anti-CD28 (human), PE, clone CD28.2 validated for use in IP, IHC & Flow Cytometry for the detection of CD28.

Analysis Note

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.25 µg of this antibody detected CD28 in one million human peripheral blood lymphocytes.

技术参数 Specifications

biological source	mouse
Quality Segment	100
conjugate	PE
antibody form	purified antibody
antibody product type	primary antibodies
clone	CD28.2, monoclonal
species reactivity	human
packaging	pkg of 5 μL (0.25 μg/test)
technique(s)	flow cytometry: suitable,immunohistochemistry: suitable,immunoprecipitation (IP): suitable
isotype	IgG1κ
UniProt accession no.	P10747
shipped in	wet ice
target post-translational modification	unmodified
Gene Information	human ... CD28(940)

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