- 商品介绍
- 规格参数
- 包装参数
General description
A highly basic, cell-permable, nonapeptide that acts as a selective myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM). Does not block calmodulin (CaM) or inhibit the kinase activities of Ca2+/calmodulin kinase II (CaMKII) or protein kinase A (PKA). Inhibition is competitive with respect to substrate (Ki = 52 nM). Displays mixed mode inhibition with respect to ATP.
A highly basic, cell-permeable, nonapeptide that acts as a selective Myosin Light Chain Kinase (MLCK) inhibitor (IC50 = 50 nM). The inhibition is competitive with respect to the peptide substrate (Ki = 52 nM) and displays a mixed mode of inhibition with respect to ATP. Does not interfere with kinase activation by calmodulin (CaM), nor does it inhibit the activities of CaMKII and PKA.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Mlck
Product does not compete with ATP.
Reversible: no
Target IC50: 50 nM against MLCK
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂
Zolotarevsky, Y., et al. 2002. Gastroenterology123, 163.
Lukas, T.J., et al. 1999. J. Med. Chem.42, 910.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Level | 100 |
| assay | ≥97% (HPLC) |
| form | lyophilized solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic) |
| color | white |
| solubility | water: 1 mg/mL,DMSO: 5 mg/mL |
| shipped in | wet ice |
| storage temp. | −20°C |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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询价
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¥ 2707.32
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¥ 6894.69
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¥ 2883.61
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¥ 4897.21
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¥ 4020.77
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¥ 1351.48
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¥ 64659.66
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