SMC®淀粉样蛋白1-40高灵敏度免疫分析试剂盒，96WELLS，03-0145-00，密理博

General description

Amyloid Beta 1-40 (Aβ1-40) is a peptide that arises from the proteolytic cleavage of the amyloid precursor protein (APP), a transmembrane protein thought to be involved in neuronal development and function. Aβ1-40 is one of the most common isoforms generated from APP, alongside Aβ1-42, which is more toxic and associated with the formation of amyloid plaques in neurodegenerative diseases.
Aβ1-40 plays a significant role in the pathophysiology of Alzheimer′s disease. Elevated levels of Aβ1-40 in the brain can contribute to neuroinflammation and neuronal damage, disrupting cell signaling and promoting the formation of amyloid plaques. These plaques are characteristic of AD and are believed to trigger a cascade of neurodegenerative processes, leading to cognitive decline and other symptoms associated with the disease. Understanding the function and implications of Aβ1-40 is essential for developing effective diagnostic tools and therapeutic strategies aimed at mitigating its harmful effects in neurodegenerative conditions.

Application

Neuroscience/Neurological Disorders/Signaling

Features and Benefits

• Exceptional Sensitivity: Detects Amyloid Beta 1-40 at femtogram levels, significantly outperforming conventional ELISA methods.
• Wider Dynamic Range: Minimizes background interference to deliver clearer signals and improved assay reliability.
• Optimized Workflow Efficiency: Automation-compatible reagents streamline lab processes and reduce manual intervention.
• Experienced Technical Support: Supported by skilled field scientists and technical teams with expertise in SMC^® assays.

Packaging

96 well assay

Analysis Note

• Sensitivity: LLOQ 5,860 fg/mL* (SMCxPRO^® instrument)
• Standard Curve Range: 340-350,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <10%
• Linearity: Plasma: 104% CSF: 109%
• Recovery: Plasma 110% CSF: 100%

Other Notes

Although Amyloid Beta 40 was detectable in mouse and rat samples, the assay has not been verified for these species.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.