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General description
Integrin beta-1 (UniProt P05556; also known as CD29, Glycoprotein Iia, GPIIA, Integrin VLA-4 subunit beta, Very late activation protein, beta polypeptide) is encoded by the ITGB1 (also known as FNRB, MDF2, MSK12, VLA-BETA, VLAB) gene (Gene ID 3688) in human. Integrin beta-1 is a 130 kDa transmembrane glycoprotein that interact with various integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptor complexes that bind to specific extracellular matrix proteins. Integrin receptors regulate a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor growth and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to the activation of signal transduction pathways and regulation of gene expression.
~192 kDa observed
Immunogen
Purified human β1 Integrin preparation from HT1080 fibrosarcoma cell extract
Application
Research Category
Cell Structure
Research Sub Category
ECM Proteins
This Anti-Integrin β1 Antibody, clone 12G10 is validated for use in Western Blotting, Flow Cytometry, Immunofluorescence for the detection of Integrin β1.
Western Blot Analysis: 0.5 µg/mL from a representative lot detected Integrin β1 in 10 µg of Integrin purified protein.
Immunofluorescence Analysis: A representative lot was used in an independent laboratory in mouse lung tissue. (Chen P., et al. (2009). PLoS ONE. 4(8):e6565.)
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in PBS containing 0.1% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
HeLa cells
Evaluated by Flow Cytometry in HeLa cells.
Flow Cytometry Analysis: 1 µg of this antibody detected Integrin β1 in HeLa cells.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: MAB2247
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Level | 100 |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 12G10, monoclonal |
| species reactivity | human |
| technique(s) | flow cytometry: suitable,immunofluorescence: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NM_002211 |
| UniProt accession no. | P05556 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... ITGB1(3688) |
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