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General description
KCHIP2, also known as Kv channel-interacting protein 2 (KChIP2), or A-type potassium channel modulatory protein 2, or Potassium channel-interacting protein 2, and encoded by the gene Kcnip2/Kchip2, is the regulatory subunit of the Kv4/D Shal-type voltage gated inactivating potassium channel. KCHIP2 modulates the activities of Kv4.2 and Kv4.3 potassium channels. KCHIP2 is localized to the cell membrane but is a peripheral membrane protein. KCHIP2 is expressed in heart, brain and lung. In brain, KCHIP2 is abundantly expressed in striatum, hippocampus, and olfactory bulb, but moderate to low expression is seen in cerebral cortex thalamus and hypothalamus. KCHIP2 has multiple isoforms in the different tissues. Isoform 1 is predominant in cerebral cortex, striatum and hippocampus, and all three isoforms are equally expressed in olfactory bulb, but in heart only isoform 3 predominates.
~ 35 kDa observed. Uncharacterized band(s) may appear in some lysates.
Immunogen
GST-tagged recombinant protein corresponding to rat KChIP2 potassium channel subunit.
Application
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected KChIP2 potassium channel subunit in human cerebral cortex tissue.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
This Anti-KChIP2 potassium channel subunit Antibody, clone 60/73 is validated for use in western blotting & IHC for the detection of KChIP2 potassium channel subunit.
Biochem/physiol Actions
This antibody does not cross react with rat KChIP1 and KChIP3 (Prof. J. Trimmer, University of California, Davis).
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected KChIP2 potassium channel subunit in 10 µg of mouse brain tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 60/73, monoclonal |
| species reactivity | rat, human, mouse |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_001029133 |
| UniProt accession no. | Q9JM59 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... KCNIP2(30819) |
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