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General description
Translocation protein SEC62, also known as Translocation protein 1 (TP-1) or (hTP-1), and encoded by the gene name SEC62, is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex. This complex is the central component of the protein translocation apparatus of the ER membrane. It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.
~31 and ~43 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Immunogen
Epitope: C-terminus
KLH-conjugated synthetic peptide corresponding to the C-terminus of human SEC62.
Application
Anti-SEC62 Antibody detects level of SEC62 & has been published & validated for use in SEC62.
Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected SEC62 in mouse brain tissue.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Biochem/physiol Actions
This antibody is predicted to not cross-react with other SEC proteins.
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 0.5 μg/mL of this antibody detected SEC62 in rat brain tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | mouse, rat |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| UniProt accession no. | Q99442 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... SEC62(7095) |
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