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CHK2 Protein, active, 10 µg，10UG，14-347，Sigma

销售价： ¥ 5722.55 / 件

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订货号： 0BV5859

品牌型号： Sigma 14-347

货期：询货期

最小订货量： 1件

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商品介绍
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包装参数

产品介绍 Product Description

General description

CHK2
Recombinant human CHK2, residues 5-543, containing N-terminal GST and Cterminal His6 tags

Biochem/physiol Actions

Protein Target: CHK2
Target Sub-Family: CAMK

Packaging

Also available in 10 μg size and in bulk
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-347M when ordering the 250 µg size.

Physical form

glutathione-agarose and Ni²⁺/NTA-agarose

Preparation Note

1 year at -70°C

Analysis Note

routinely evaluated by phosphorylation of the CHKtide substrate peptide

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	human
Quality Segment	100
recombinant	expressed in E. coli
product line	Upstate^®
specific activity	(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
mol wt	M_w 89.6 kDa
purified by	(glutathione-agarose and Ni²⁺/NTA-agarose)
species reactivity	human
manufacturer/tradename	Upstate^®
technique(s)	activity assay: suitable (kinase)
accession no.	(FUNCTION: SwissProt: O96017 # Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on ′Ser-216′, preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at ′Thr-18′ and ′Ser-20′. ),NM_001005735.1
NCBI accession no.	NM_001005735.1,NM_007194.3,NM_145862.2
UniProt accession no.	O96017
Gene Information	human ... CHEK2(11200)

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