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- 规格参数
- 包装参数
General description
Zinc finger protein 593 (UniProt: O00488; also known as Zinc finger protein T86) is encoded by the ZNF593 (also known as ZT86) gene (Gene ID: 51042) in human. Zinc fingers are small protein domains wherein zinc plays a structural role contributing to the stability of the domain. Proteins containing zinc fingers are structurally diverse and perform a broad range of functions, including DNA replication and repair, transcription and translation, metabolism, cell proliferation, and apoptosis. Zinc finger domain 593 (ZNF593) belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family and contains a single C2H2 type zinc finger (amino acids 61-85). ZFP593 is largely disordered, with the exception of the zinc finger domain. It displays ubiquitous distribution and has been detected in spleen, prostate, testis, small intestine, and colon and in lower levels in thymus and peripheral blood leukocytes. ZFP593 is shown to negatively modulate the DNA binding activity of Oct-2. It can act either by binding to DNA octamer or by interacting with Oct-2. (Ref.: Srikrishna, S., et al. (2003), Nucleic Acid Res. 31(2): 532-550).
~15 kDa observed. 15.20 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Immunogen
KLH-conjugated linear peptide corresponding to 14 amino acids from the C-terminal end of human Zinc finger protein 593.
Application
Anti-Zinc finger protein 593 Antibody, Cat. No. ABE1358, is a highly specific rabbit polyclonal antibody that targets Zinc finger protein 593 and has been tested in Immunoprecipitation and Western Blotting.
Research Category
Epigenetics & Nuclear Function
Western Blotting Analysis: A 1:500 dilution from a representative lot detected Zinc finger protein 593 in mouse embryonic stem cells. (Courtesy of Dr Adrian Bracken from Trinity College, Dublin).
Immunoprecipitation Analysis: 2 ug from a representative lot detected Zinc finger protein 593 in mouse embryonic stem cells. (Courtesy of Dr Adrian Bracken from Trinity College, Dublin).
Biochem/physiol Actions
This polyclonal antibody detects zinc finger protein 593 in murine embryonic stem cells. It targets an epitope of 14 amino acids from the C-terminus.
Physical form
Affinity Purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in mouse embryonic stem cells.
Western Blotting Analysis: A 1:500 dilution of this antibody detected Zinc finger protein 593 in 10 µg of mouse embryonic stem cells lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | mouse |
| species reactivity (predicted by homology) | bovine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), human (based on 100% sequence homology) |
| technique(s) | immunoprecipitation (IP): suitable,western blot: suitable |
| NCBI accession no. | NP_056955 |
| UniProt accession no. | O00488 |
| shipped in | ambient |
| target post-translational modification | unmodified |
| Gene Information | mouse ... Zfp593(68040) |
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