- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable, symmetrical sulfonated urea compound that acts as a potent, specific and non-AdoMet (S-adenosyl-L-methionine, SAM)-competitive inhibitor of protein arginine N-methyltransferases (PRMTs; IC50 = 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p) with minimal effect on lysine methyltransferases. Inhibits nuclear receptor reporter gene activation in MCF-7 cells, and HIV-1 RT polymerase (IC50 = 5 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Protein arginine N-methyltransferases (PRMTs)
Product does not compete with ATP.
Reversible: no
Target IC50: 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
Skillman, A.G., et al. 2002. Bioorg. Chem.30, 443.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic),protect from light |
| solubility | water: 50 mg/mL |
| shipped in | ambient |
| storage temp. | −20°C |
| 长度(mm) | |
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询价
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¥ 2622.09
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¥ 1573.49
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¥ 1866.29
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¥ 3109.49
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¥ 3442.25
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¥ 6894.69
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¥ 10277.12
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¥ 2842.54
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¥ 3319.60
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¥ 1476.40
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¥ 2288.54
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¥ 56581.65
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