Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211，50UG，MAB5264，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells.
75 kDa

Immunogen

Membrane fragments of the melanoma cell line WM-9 (Herlyn et al., 1983).

Application

Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211 is an antibody against Nerve Growth Factor Receptor (p75) for use in IC, IH, IH(P) & WB.
Immunohistochemistry: 5-10 μg/mL

Immunocytochemistry: 5-10 μg/mL

Immunohistochemistry on paraffin sections: Cattoretti, Blood 81:1726-1738, 1993. http://www.bloodjournal.org/cgi/reprint/81/7/1726.pdf

Western Blot: 1ug/mL

Immunoabsorptive purification of NGF-receptors

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

Reacts with NGF-receptors in human system.

Physical form

Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 04-1111

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

技术参数 Specifications

biological source	mouse
Quality Level	100
conjugate	unconjugated
antibody form	purified antibody
antibody product type	primary antibodies
clone	8211, monoclonal
species reactivity	human
manufacturer/tradename	Chemicon^®
technique(s)	immunocytochemistry: suitable,immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable,western blot: suitable
isotype	IgG1
NCBI accession no.	NM_002507.2
UniProt accession no.	P08138
shipped in	wet ice
target post-translational modification	unmodified
Gene Information	human ... NTF3(4908)

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