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Anti-NCoA-2 Antibody，100UG，07-1799，Sigma

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订货号： 0BV6273

品牌型号： Sigma 07-1799

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最小订货量： 1件

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产品介绍 Product Description

General description

NCoA2 (nuclear receptor coactivator 2) is a transcriptional coactivator for steroid receptors and nuclear receptors. Also known as glucocorticoid receptor interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2), this coregulatory protein contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCoA-2 assists nuclear receptors in the upregulation of DNA expression. In cells ligand activated nuclear receptors recruit NCoA-2 to DNA where it acylates histones to make targeted regions accessible to transcriptional machinery.

~ 160 kDa

Immunogen

Epitope: Unknown
Linear peptide corresponding to human NCoA-2

Application

Chromatin Immunoprecipitation:
A representative lot of this antibody was used for chIP. See Monroe, D.G., et al. (2006) J. Biol. Chem. 281(39):28596-28604.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Use Anti-NCoA-2 Antibody (rabbit polyclonal antibody) validated in WB to detect NCoA-2 also known as Transcriptional intermediary factor 2, glucocorticoid receptor-interacting protein-1, nuclear receptor coactivator 2.

Biochem/physiol Actions

Homology to mouse and rat is 95%.
This antibody recognizes NCoA-2.

Physical form

Affinity purified
Format: Purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
U2 OS cell lysate
Evaluated by Western Blot in U2 OS cell lysate.

Western Blot Analysis: 0.5 µg/ml of this antibody detected SRC2 on 10 µg of U2 OS cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
species reactivity	human
technique(s)	ChIP: suitable,western blot: suitable
isotype	IgG
NCBI accession no.	NP_006531.1
UniProt accession no.	Q15596
shipped in	wet ice
target post-translational modification	unmodified
Gene Information	human ... NCOA2(10499)

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