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Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2，250UG，MAB394-250UG，Sigma

销售价： ¥ 42474.59 / 件

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订货号： 0BV6662

品牌型号： Sigma MAB394-250UG

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最小订货量： 1件

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产品介绍 Product Description

Application

Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2 detects level of Dopamine β Hydroxylase & has been published & validated for use in 0.

Biochem/physiol Actions

Dopamine b-HydroxylaseDBH is a single gene product that exists as a cytosolic enzyme, as a membrane protein and is secreted into the circulation (Lewis & Asnani, 1992). Because of its residence time as a plasma membrane-bound protein, it is able to be used as a targeting agent for neurons. The target neurons include postganglionic sympathetic neurons and all noradrenergic and adrenergic neurons of the central nervous system. As such anti-DBH-SAP can be used for the production of acute peripheral autonomic failure in a model for the human disease. It can also be used for the analysis of the behavioral effects of noradrenergic or adrenergic ablation. When injected intraventricularly, noradrenergic neurons of the locus coeruleus are eliminated (Wiley & Lappi, 1994). The antibody and immunotoxin undergo retrograde transport.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

技术参数 Specifications

biological source	mouse
Quality Segment	100
conjugate	saporin
antibody product type	primary antibodies
clone	4F10.2, monoclonal
species reactivity	rat
packaging	antibody small pack of 25 μg
manufacturer/tradename	Chemicon^®
technique(s)	immunolesioning: suitable
isotype	IgG1
NCBI accession no.	NM_000787.3
UniProt accession no.	P09172
shipped in	wet ice
target post-translational modification	unmodified
Gene Information	rat ... Dbh(25699)

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