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General description
Protein notum homolog (NOTUM) is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by β-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway. In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein.
~73 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Immunogen
Epitope: N-terminus
KLH-conjugated synthetic peptide corresponding to the N-terminus of human NOTUM.
Application
Anti-NOTUM Antibody is an antibody against NOTUM for use in western blotting, IHC & immunofluorescence.
Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected NOTUM in human brain tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected NOTUM in mouse kidney cells.
Research Category
Signaling
Research Sub Category
Developmental Signaling
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in human kidney tissue lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected NOTUM in human kidney tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | mouse, human |
| technique(s) | immunofluorescence: suitable,immunohistochemistry: suitable,western blot: suitable |
| UniProt accession no. | Q6P988 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... NOTUM(147111) |
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