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General description
Calcineurin/PP2B Aβ, also known as Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, and encoded by the gene PPP3CB/CALNA2/CALNB/CNA2, is a calcium dependent, calmodulin stimulated catalytic subunit protein phosphatase critical in the function of Calcineurin an important phosphatase governing immune responses such as T cell activation and the T cell immune response. Calcineurin is a heterodimeric protein consisting of a catalytic subunit Calcineurin A, which contains an active site dinuclear metal center, and a tightly associated, myristoylated, Ca(2+)-binding subunit, Calcineurin B. Calcineurin/PP2B Aβ is the beta isoform of the catalytic active site of the subunit A of Calcineurin. Calcineurin also plays pivotal roles in signaling transduction cascades in a variety of other immune cells as well as non-immune cells like myocytes and neurons.
~57 kDa observed
Immunogen
Epitope: Near C-terminus
KLH-conjugated linear peptide corresponding to rat Calcineurin A/PP2B catalytic unit near the C-terminus.
Application
Immunoprecipitation Analysis: 5 µg from a representative lot immunoprecipitated Calcineurin A/PP2B catalytic unit in 500 µg of mouse brain tissue lysate.
Research Category
Signaling
Research Sub Category
Metabolic Hormones & Receptors
This Anti-Calcineurin A/PP2B catalytic unit antibody is validated for use in western blotting & IP for the detection of Calcineurin A/PP2B catalytic unit.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in human brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Calcineurin A/PP2B catalytic unit in 10 µg of human brain tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: 07-068
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human, rat, mouse |
| technique(s) | immunoprecipitation (IP): suitable,western blot: suitable |
| NCBI accession no. | NP_058738 |
| UniProt accession no. | P20651 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... PPP3CA(5530) mouse ... Ppp3Ca(19055) rat ... Ppp3Ca(24674) |
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