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General description
WW domain-containing oxidoreductase (WWOX) is also called Fragile site FRA16D oxidoreductase (FOR). WWOX is a putative oxidoreductase that functions as a tumor suppressor and is involved in apoptosis. WWOX is also required for normal bone development, and inhibits Wnt signaling. WWOX is widely expressed, but is most strongly expressed in testis, prostate, and ovary as well as in cancer cell lines. Certain isoforms (Isoform 5 and isoform 6) are thought to only be expressed in tumor cell lines. WWOX is linked to several cancer types like Esophageal cancer (ESCR).
~46 kDa observed
Immunogen
Recombinant protein corresponding to mouse WWOX.
Application
Anti-WWOX Antibody, clone 12G5 | MABN1594 is an antibody against WWOX Antibody for use in Western Blotting, Immunohistochemistry.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected WWOX in 10 µg of mouse 11 day embreyo and mouse E13-14 Brain tissue lysate.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected WWOX in human cerebellum and human cerebral cortex tissue.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected WWOX in mouse cerebellum and mouse hindbrain tissue.
Physical form
Format: Purified
Protein G Purified
Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in HepG2 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected WWOX in 10 µg of HepG2 cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rat |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 12G5, monoclonal |
| species reactivity | mouse, human |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG2aκ |
| NCBI accession no. | NP_062519 |
| UniProt accession no. | Q91WL8 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... WWOX(51741) |
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